28^th European Nephrology Conference

CRISPR and Gene Editing in Nephrology: Precision Medicine Approaches

CRISPR and gene editing have emerged as revolutionary tools in nephrology, offering promising avenues for precision medicine. In this rapidly evolving field, researchers are exploring how genetic manipulation can address various renal disorders with unparalleled precision. From targeting genetic mutations underlying inherited kidney diseases to potentially engineering immune cells for transplant tolerance, CRISPR technology holds immense therapeutic potential. One promising application is in polycystic kidney disease (PKD), where CRISPR enables targeted correction of disease-causing mutations. Additionally, gene editing may facilitate personalized treatments for kidney cancer by modifying genetic pathways driving tumor growth. Furthermore, CRISPR-based approaches hold promise in addressing the shortage of viable donor organs through xenotransplantation, where pig kidneys are modified for human compatibility. However, ethical considerations and off-target effects remain significant challenges. Despite this, ongoing research in CRISPR and gene editing within nephrology underscores a transformative shift towards tailored, precision therapies, offering hope for improved outcomes and quality of life for patients with kidney disorders.