29^th European Nephrology Conference

Pharmacogenomics in Renal Drug Response

Pharmacogenomics is transforming renal drug therapy by personalizing treatment based on genetic variations that influence drug response. Individual genetic profiles can significantly impact how patients metabolize and respond to medications used in managing renal conditions, such as hypertension, diabetes, and chronic kidney disease. For example, genetic variations in drug-metabolizing enzymes like CYP450 can affect the efficacy and safety of antihypertensive agents and diabetes medications. Pharmacogenomic testing helps identify patients who may be at risk of adverse drug reactions or those who may require dose adjustments to achieve optimal therapeutic outcomes. By integrating genetic information into prescribing practices, healthcare providers can tailor treatments to individual needs, reducing the risk of side effects and enhancing therapeutic efficacy. As the kidneys play a vital role in drug elimination, variations in genes encoding drug-metabolizing enzymes, transporters, and receptors can significantly impact drug efficacy and toxicity.