29^th European Nephrology Conference

CRISPR Innovations for Kidney Disorders

CRISPR technology has revolutionized the field of genetic medicine, offering promising solutions for kidney disorders. By utilizing CRISPR-Cas9, researchers can precisely edit genes associated with various kidney conditions, such as polycystic kidney disease  and focal segmental glomerulosclerosis. For PKD, CRISPR can potentially correct mutations in the PKD1 and PKD2 genes, which are responsible for cyst formation and progressive kidney failure. Similarly, in FSGS, CRISPR can be used to target mutations in genes like NPHS2, which impair kidney function. Recent advancements in delivery methods, including nanoparticle-based systems, enhance CRISPR's precision and reduce off-target effects, improving safety and efficacy. These innovations pave the way for personalized gene therapies that could halt or even reverse kidney disease progression, offering hope for patients who currently have limited treatment options. As research progresses, CRISPR holds the potential to significantly transform the management of kidney disorders.