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Punit Gupta

Sharda super specialty hospital, Delhi NCR, India

Title: To analyze various changes in the red blood cell (RBC) parameters in patients with chronic kidney disease (CKD) and to correlate it with the stage of the disease a study from Tertiary care hospitalOf Delhi NCR

Biography

Biography: Punit Gupta

Abstract

Aim:

Anemia is a common sequealae of chronic kidney disease (CKD), associated with significant morbidity. The study was conducted to know hematological manifestations in patients of Chronic Kidney Disease admitted to Dept of Nephrology and organ transplantation ,Shardasuperspecialtly hospital, delhincr

Material & Methods:

Renal diseases are associated with a variety of hematological changes, and anemia is the most predominant feature   . 55 patients with Chronic Kidney Disease admitted in Nephrology Unit were studied. All patients were subjected to all routine investigations including Complete Blood Count, Blood Sugar, RFT & electrolytes and other relevant tests.

Results:

·         Mean Age of the patients was 49.5 + 8.5 years.

·         69.3% patients were males and 30.7% patients were females.

·         As per the WHO criteria for anemia grading , following are the anemia with severity graging in ckd patients

·         Stage wise distribution of patients in stage I, II, IIIa,111b, IV, and V was nil, 3.6%, 3.6%, 1.8%, 9.09%& 81.1% respectively

·         Ckd stage from stage 2 to 3b ,patients had mild anemia and from ckd stage 4 to 5 patients have moderate to life threatening anemia .( as per WHO grading).

·         Among patients with Hemoglobin > 11 gm/dl, % 3.6were diabetic and 7.2% were non diabetic.

·         Normocytic, normochromic anemia was the most common abnormality and was found in 65% of patients having Hemoglobin < 10 gm/dl.

·         Microcytic Hypochromic anemia was found in 30% of patients and rest patients had normocytic, hypochromic anemia.

 

Conclusion:

·         Hemoglobin level drops with increasing stages of ckd.

·         Higher proportion of diabetic patients was found in the group having hemoglobin less than 11 gm/dl.

·         Maximum number of patients was in mild grading of anemia in our study.

·         Most of the patients having moderate to severe anemia were in ckd stage 5 as per our study.

Normocytic, Normochromic Anemia was the most common peripheral smear finding among Chronic Kidney Disease patients.